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[Ebook.v7o2] Developability of Biotherapeutics Computational Approaches

[Ebook.v7o2] Developability of Biotherapeutics Computational Approaches

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Book Details :
Published on: 2015-12-14
Released on:
Original language: English

Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism. The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book also addresses a general lack of awareness of the many different contributions that computation can make to biopharmaceutical drug development. This informative and practical reference is a valuable resource for professionals engaged in industrial research and development, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators. It focuses primarily on the developability of monoclonal antibody candidates, but the principles described can also be extended to other modalities such as recombinant proteins, fusion proteins, antibody drug conjugates and vaccines. The book is organized into two sections. The first discusses principles and applications of computational approaches toward discovering and developing biopharmaceutical drugs. The second presents best practices in developability assessments of early-stage biopharmaceutical drug candidates. In addition to raising awareness of the promise of computational research, this book also discusses solutions required to improve the success rate of translating biologic drug candidates into products available in the clinic. As such, it is a rich source of information on current principles and practices as well as a starting point for finding innovative applications of computation towards biopharmaceutical drug development. Engineering Antibodies The field of protein engineering is at an exciting point in its development with new generations of therapeutic antibodies now reaching the market great advances in ... Cetuximab-Induced Anaphylaxis and IgE Specific for ... Original Article. Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose--13-Galactose. Christine H. Chung M.D. Beloo Mirakhur M.D. Ph.D. Emily Chan M ... Posters - PEGS Europe Preliminary List of Poster Titles. AbCheck SRO - How affinity translates into a selective advantage: A Comparison of Phage and Yeast Display for Rabbit Mass Humanization Conferences and Meetings on Pharmacology and Drug Development Conferences and Meetings on Pharmacology and Drug Development. Conference-Service.com offers as part of our business activities a directory of upcoming scientific ... 10.1021/ac3032355 - ACS Publications Home Page Laboratoire de Spectromtrie de Masse BioOrganique (LSMBO) Universit de Strasbourg IPHC 25 rue Becquerel 67087 Strasbourg France and CNRS UMR7178 67037 ... Protein Purification Technologies Conference Cambridge Healthtech Institutes 2nd Annual Protein Purification Technologies Streamlining Processes to Achieve Quality 3 - 4 November 2016 EPIC SANA Lisboa ... Speaker Biographies - biotherapeuticsanalyticalsummit.com Speaker Biographies. Method Development Qualification & Validation March 20-21 2017. Elena Belitsky Ph.D. Director QC Clinical Operations Biogen Cytokine Storm in a Phase 1 Trial of the Anti-CD28 ... Audio Interview. Interview with Ganesh Suntharalingam on the severe illness and treatment of the volunteers in the recent trial of the TGN1412 monoclonal antibody.
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